منابع مشابه
Antitrypanasomal activity of novel benzaldehyde-thiosemicarbazone derivatives from kaurenoic acid.
A series of new thiosemicarbazones derived from natural diterpene kaurenoic acid were synthesized and tested against the epimastigote forms of Trypanosoma cruzi to evaluate their antitrypanosomal potential. Seven of the synthesized thiosemicarbazones were more active than kaurenoic acid with IC₅₀ values between 2-24.0 mM. The o-nitro-benzaldehyde-thiosemicarbazone derivative was the most active...
متن کاملNovel Derivatives of Kaurenoic Acid: Preparation and Evaluation of their Trypanocidal Activity
Henriete S. Vieira, Jacqueline A. Takahashi, Alaíde B. de Oliveira, Egler Chiari and Maria Amélia D. Boaventura* Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte MG, Brazil Departamento de Produtos Farmacêuticos, Faculdade de Farmácia , Universidade Federal de Minas Gerais, Av. Olegário Maciel, 2360,...
متن کاملSemi-Synthesis of Kaurenoic Acid Derivatives and Their In Vitro Cytotoxic Activities
Lei Zhang1, Fei Wang1, Xin-hua Ma1, Fang Zhou1, Sheng-mei Wen1, Tian-hua Zhong2, Quan-yu Liu1, Shi-wu Chen3, Yong-hong Zhang1 1 Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China 2 Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, P.R. China 3 School...
متن کاملiso-Kaurenoic acid from Wedelia paludosa D.C.
A recent reinvestigation of aerial parts of Wedelia paludosa D.C. is described and reports, for the first time, the isolation of iso-kaurenoic acid from this species.
متن کاملMicrobial transformation of ent-kaurenoic acid and its 15-hydroxy derivatives by the SG138 mutant of Gibberella fujikuroi.
Feeding experiments with ent-kaurenoic acid (4), 15 alpha-hydroxy-ent-kaurenoic acid (5), 15 beta-hydroxy-ent-kaurenoic acid (6), and mixtures of 4 plus 5 and 4 plus 6 were conducted using the SG138 mutant of Gibberella fujikuroi, to gain information about the phenotype of this unique strain. The biotransformation of 5 gave 7 beta,15 alpha-dihydroxykaurenolide (9) and 7 beta,15 alpha-dihydroxy-...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2002
ISSN: 0103-5053
DOI: 10.1590/s0103-50532002000200004